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Abstract Background PraderWilli syndrome is a rare neuroendocrine genetic disorder that causes hypothalamic dysfunction, hyperphagia, and morbid obesity

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The French study showed a significant increase in mortality for bone tumors in a cohort of about 6,500 young adult subjects treated with r-hGH during childhood for the indications of isolated GH deficiency (IGHD), short stature associated with small for gestational age (SGA), or idiopathic short stature (ISS) [51]

These include allergic reactions, which can be very serious